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Arginina ed eiaculazione precoce

Usi dell'arginina

Riferimento bibliografico

1. [L-arginine and male infertility]
Scibona M, Meschini P, Capparelli S, Pecori C, Rossi P, Menchini Fabris GF.
Minerva Urol Nefrol. 1994 Dec;46(4):251-3. Italian.
PMID: 7701414 [PubMed - indexed for MEDLINE]
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Scuola di Specializzazione in Andrologia, Università degli Studi di Pisa.

(Abstract)
The clinical efficacy and acceptance of L-arginina HCL was tested in 40 infertile men. All of these men had a normal number of spermatozoa (> 20 million/ml), but a decreased motility; this decreased motility was not due to infection or to immunological disorders. The treatment consisted of 80 ml of 10% L-arginine HCL administered daily per os for 6 months. L-arginine HCL showed to be able to improve the motility of spermatozoa without any side-effects.

2. The clinical use of arginine aspartate in male infertility.
De Aloysio D, Mantuano R, Mauloni M, Nicoletti G.
Acta Eur Fertil. 1982 Sep;13(3):133-67. English, Italian.
PMID: 6820754 [PubMed - indexed for MEDLINE]
Related citations


3. Studies on arginine in human semen. 3. The influences of several drugs on male infertility.
Tanimura J.
Bull Osaka Med Sch. 1967 Oct;13(2):90-100. No abstract available.
PMID: 6080243 [PubMed - indexed for MEDLINE]
Related citations


4.Studies on arginine in human semen. II. The effects of medication with L-arginine-HCL on male infertility.
Tanimura J.

Bull Osaka Med Sch. 1967 Oct;13(2):84-9. No abstract available.
PMID: 6080242 [PubMed - indexed for MEDLINE]
Related citations

5.Effects of arginine in the treatment of male infertility (author's transl)
Rugna DD, Stahel T.
Schweiz Rundsch Med Prax. 1976 Apr 20;65(16):481-5. German. No abstract available.
PMID: 981167 [PubMed - indexed for MEDLINE]


L’eiaculazione precoce (EP) e' una condizione medica frequente, in particolare e' la disfunzione sessuale piu' comune e in Italia ne soffre un uomo su cinque nella fascia di eta' compresa tra 18 e 70 anni. 1, 2 Secondo le principali societa' scientifiche internazionali, come l’International Society for Sexual Medicine, l’American Urological Association e l’European Association of Urology, la definizione di EP si basa sui seguenti criteri chiave:
• eiaculazione che si verifica, in modo persistente o ricorrente, in seguito a stimolazione sessuale minima, prima o durante la penetrazione vaginale;
• mancanza di controllo eiaculatorio;
• conseguenze negative a livello personale, come frustrazione.
L’uomo che soffre di EP spesso prova scarsa autostima, disagio, frustrazione, addirittura puo' soffrire anche di ansia e depressione. L’EP ha un impatto negativo anche sulla partner, determinando un livello di frustrazione e di insoddisfazione sessuale sovrapponibile a quello dell’uomo con seria compromissione del rapporto di coppia.
Considerata inizialmente un problema psicologico, l’EP e' stata trattata per decenni con terapie non farmacologiche, quali la terapia comportamentale, e con la riduzione della sensibilita' peniena mediante anestetici topici (spray, creme, ecc.). 9, 10 Tuttavia, queste terapie non solo non apportano importanti benefici soprattutto a lungo termine ma, anzi, rispettivamente, sono causa di perdita di spontaneita' in un normale rapporto sessuale o possono indurre effetti collaterali importanti sia nell’uomo che nella partner. 9, 10
Successivamente, e' stato dimostrato che alla base dell’EP agiscono meccanismi neurobiologici, ossia che l’eiaculazione e' sotto il controllo e la mediazione del sistema nervoso centrale.
La serotonina, in particolare, e' un neurotrasmettitore in grado di controllare l’eiaculazione e la risposta sessuale maschile. L’eiaculazione precoce e' associata a una ridotta concentrazione di serotonina. Un aumento dei livelli di serotonina a livello del sistema nervoso centrale svolge un’azione inibitoria sull’eiaculazione, ritardandola.



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